Advertisement
Research Article

Evolutionarily Repurposed Networks Reveal the Well-Known Antifungal Drug Thiabendazole to Be a Novel Vascular Disrupting Agent

  • Hye Ji Cha,

    Affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Michelle Byrom,

    Affiliation: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Paul E. Mead,

    Affiliation: Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America

    X
  • Andrew D. Ellington,

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, United States of America

    X
  • John B. Wallingford mail,

    wallingford@mail.utexas.edu (JBW); marcotte@icmb.utexas.edu (EMM)

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Howard Hughes Medical Institute & Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Edward M. Marcotte mail

    wallingford@mail.utexas.edu (JBW); marcotte@icmb.utexas.edu (EMM)

    Affiliations: Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, United States of America

    X
  • Published: August 21, 2012
  • DOI: 10.1371/journal.pbio.1001379

About the Authors

Hye Ji Cha, Michelle Byrom, Andrew D. Ellington, John B. Wallingford, Edward M. Marcotte
Center for Systems and Synthetic Biology, Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America
Paul E. Mead
Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America
Andrew D. Ellington, Edward M. Marcotte
Department of Chemistry and Biochemistry, University of Texas at Austin, Austin, Texas, United States of America
John B. Wallingford
Howard Hughes Medical Institute & Section of Molecular Cell and Developmental Biology, University of Texas at Austin, Austin, Texas, United States of America

Corresponding Authors

Competing Interests

A patent application based on this work has been filed. The authors have declared that no other competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HJC JBW EMM. Performed the experiments: HJC MB. Analyzed the data: HJC JBW EMM. Contributed reagents/materials/analysis tools: PEM ADE. Wrote the paper: HJC ADE JBW EMM.