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Research Article

The Germinal Center Kinase TNIK Is Required for Canonical NF-κB and JNK Signaling in B-Cells by the EBV Oncoprotein LMP1 and the CD40 Receptor

  • Anna Shkoda equal contributor,

    equal contributor Contributed equally to this work with: Anna Shkoda, Jennifer A. Town

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

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  • Jennifer A. Town equal contributor,

    equal contributor Contributed equally to this work with: Anna Shkoda, Jennifer A. Town

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Janine Griese,

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Michael Romio,

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Hakan Sarioglu,

    Affiliation: Research Unit Protein Science, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Thomas Knöfel,

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Fabian Giehler,

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

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  • Arnd Kieser mail

    a.kieser@helmholtz-muenchen.de

    Affiliation: Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

    X
  • Published: August 14, 2012
  • DOI: 10.1371/journal.pbio.1001376

About the Authors

Anna Shkoda, Jennifer A. Town, Janine Griese, Michael Romio, Thomas Knöfel, Fabian Giehler, Arnd Kieser
Research Unit Gene Vectors, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany
Hakan Sarioglu
Research Unit Protein Science, Helmholtz Zentrum München - German Research Center for Environmental Health, München, Germany

Corresponding Author

Email: a.kieser@helmholtz-muenchen.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AS JAT JG FG AK. Performed the experiments: AS JAT JG MR FG AK. Analyzed the data: AS JAT JG FG HS AK. Contributed reagents/materials/analysis tools: TK. Wrote the paper: AS JAT AK. Conceived and designed the study: AK.