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Research Article

Haemodynamics-Driven Developmental Pruning of Brain Vasculature in Zebrafish

  • Qi Chen equal contributor,

    equal contributor Contributed equally to this work with: Qi Chen, Luan Jiang

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Luan Jiang equal contributor,

    equal contributor Contributed equally to this work with: Qi Chen, Luan Jiang

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Chun Li,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Dan Hu,

    Affiliation: Department of Mathematics and Institute of Natural Sciences, Shanghai Jiaotong University, Shanghai, China

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  • Ji-wen Bu,

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • David Cai,

    Affiliations: Department of Mathematics and Institute of Natural Sciences, Shanghai Jiaotong University, Shanghai, China, Courant Institute of Mathematical Sciences and Center for Neural Science, New York University, New York, United States of America

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  • Jiu-lin Du mail

    forestdu@ion.ac.cn

    Affiliation: Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China

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  • Published: August 14, 2012
  • DOI: 10.1371/journal.pbio.1001374

About the Authors

Qi Chen, Luan Jiang, Chun Li, Ji-wen Bu, Jiu-lin Du
Institute of Neuroscience and State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
Dan Hu, David Cai
Department of Mathematics and Institute of Natural Sciences, Shanghai Jiaotong University, Shanghai, China
David Cai
Courant Institute of Mathematical Sciences and Center for Neural Science, New York University, New York, United States of America

Corresponding Author

Email: forestdu@ion.ac.cn

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: QC JLD. Performed the experiments: QC JWB. Analyzed the data: QC LJ CL DH. Contributed reagents/materials/analysis tools: LJ CL DH DC. Wrote the paper: QC JLD. Designed research, carried out all experiments, analyzed data and wrote the paper: QC. Developed analysis methods of vasculature and analyzed data: LJ CL. Performed bead microinjection and TUNEL: JWB. Performed numerical simulation: DH DC. Designed research and wrote the paper: JLD.