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Research Article

Topology and Dynamics of the Zebrafish Segmentation Clock Core Circuit

  • Christian Schröter,

    Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, Max Planck Institute for the Physics of Complex Systems, Dresden, Germany

    Current address: University of Cambridge, Department of Genetics, Downing Street, Cambridge CB2 3EH, UK

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  • Saúl Ares equal contributor,

    equal contributor Contributed equally to this work with: Saúl Ares, Luis G. Morelli

    Affiliation: Max Planck Institute for the Physics of Complex Systems, Dresden, Germany

    Current address: Logic of Genomic Systems Laboratory, Centro Nacional de Biotecnología - CSIC, Calle Darwin 3, 28049 Madrid, Spain

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  • Luis G. Morelli equal contributor,

    equal contributor Contributed equally to this work with: Saúl Ares, Luis G. Morelli

    Affiliations: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany, CONICET, Departamento de Física, Universidad de Buenos Aires, Buenos Aires, Argentina

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  • Alina Isakova,

    Affiliation: École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Life Sciences, Lausanne, Switzerland

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  • Korneel Hens,

    Affiliation: École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Life Sciences, Lausanne, Switzerland

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  • Daniele Soroldoni,

    Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Martin Gajewski,

    Affiliation: Institute for Genetics, University of Cologne, Cologne, Germany

    Current address: Hamilton Bonaduz AG, Via Crusch 8, 7402 Bonaduz, Switzerland

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  • Frank Jülicher,

    Affiliation: Max Planck Institute for the Physics of Complex Systems, Dresden, Germany

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  • Sebastian J. Maerkl,

    Affiliation: École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Engineering, Lausanne, Switzerland

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  • Bart Deplancke,

    Affiliation: École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Life Sciences, Lausanne, Switzerland

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  • Andrew C. Oates mail

    oates@mpi-cbg.de

    Affiliation: Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany

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  • Published: July 24, 2012
  • DOI: 10.1371/journal.pbio.1001364

About the Authors

Christian Schröter, Luis G. Morelli, Daniele Soroldoni, Andrew C. Oates
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany
Christian Schröter, Saúl Ares, Frank Jülicher
Max Planck Institute for the Physics of Complex Systems, Dresden, Germany
Luis G. Morelli
CONICET, Departamento de Física, Universidad de Buenos Aires, Buenos Aires, Argentina
Alina Isakova, Korneel Hens, Bart Deplancke
École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Life Sciences, Lausanne, Switzerland
Martin Gajewski
Institute for Genetics, University of Cologne, Cologne, Germany
Sebastian J. Maerkl
École Polytechnique Fédérale de Lausanne, Institute of Bioengineering, School of Engineering, Lausanne, Switzerland

Corresponding Author

Email: oates@mpi-cbg.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CS SA LGM DS SJM BD ACO. Performed the experiments: CS AI KH. Analyzed the data: CS SA LGM SJM ACO. Contributed reagents/materials/analysis tools: CS AI MG SJM. Wrote the paper: CS SA LGM SJM ACO. Developed and analyzed the mathematical model: CS SA LGM FJ ACO.