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Research Article

Regulation of DNA Replication within the Immunoglobulin Heavy-Chain Locus During B Cell Commitment

  • Agnieszka Demczuk,

    Affiliation: Department of Oncology, Montefiore Medical Center, Moses Division, Bronx, New York, United States of America

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  • Michel G. Gauthier,

    Affiliation: Department of Physics, Simon Fraser University, Burnaby, Canada

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  • Ingrid Veras,

    Affiliation: Department of Oncology, Montefiore Medical Center, Moses Division, Bronx, New York, United States of America

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  • Settapong Kosiyatrakul,

    Affiliation: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Carl L. Schildkraut,

    Affiliation: Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Meinrad Busslinger,

    Affiliation: Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria

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  • John Bechhoefer,

    Affiliation: Department of Physics, Simon Fraser University, Burnaby, Canada

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  • Paolo Norio mail

    paolo.norio@einstein.yu.edu

    Affiliations: Department of Oncology, Montefiore Medical Center, Moses Division, Bronx, New York, United States of America, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

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  • Published: July 10, 2012
  • DOI: 10.1371/journal.pbio.1001360

About the Authors

Agnieszka Demczuk, Ingrid Veras, Paolo Norio
Department of Oncology, Montefiore Medical Center, Moses Division, Bronx, New York, United States of America
Michel G. Gauthier, John Bechhoefer
Department of Physics, Simon Fraser University, Burnaby, Canada
Settapong Kosiyatrakul, Carl L. Schildkraut
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America
Meinrad Busslinger
Research Institute of Molecular Pathology, Vienna Biocenter, Vienna, Austria
Paolo Norio
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, United States of America

Corresponding Author

Email: paolo.norio@einstein.yu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: PN. Performed the experiments: PN AD IV. Analyzed the data: PN MGG JB. Contributed reagents/materials/analysis tools: MB SK CLS. Wrote the paper: PN, with limited contributions by JB and CS.