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Research Article

Small Heat Shock Proteins Potentiate Amyloid Dissolution by Protein Disaggregases from Yeast and Humans

  • Martin L. Duennwald,

    Affiliation: Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America

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  • AnaLisa Echeverria,

    Affiliation: Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America

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  • James Shorter mail

    jshorter@mail.med.upenn.edu

    Affiliation: Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Published: June 19, 2012
  • DOI: 10.1371/journal.pbio.1001346

About the Authors

Martin L. Duennwald, AnaLisa Echeverria
Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
James Shorter
Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: jshorter@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MLD JS. Performed the experiments: MLD AE JS. Analyzed the data: MLD AE JS. Contributed reagents/materials/analysis tools: MLD AE JS. Wrote the paper: JS.