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Research Article

Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy

  • Weiqin Lu equal contributor,

    equal contributor Contributed equally to this work with: Weiqin Lu, Yumin Hu

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Yumin Hu equal contributor,

    equal contributor Contributed equally to this work with: Weiqin Lu, Yumin Hu

    Affiliations: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

    X
  • Gang Chen,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Zhao Chen,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Hui Zhang,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Feng Wang,

    Affiliations: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China

    X
  • Li Feng,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Helene Pelicano,

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Hua Wang,

    Affiliation: Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Michael J. Keating,

    Affiliation: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Jinsong Liu,

    Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Wallace McKeehan,

    Affiliation: Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

    X
  • Huamin Wang,

    Affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Yongde Luo,

    Affiliation: Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

    X
  • Peng Huang mail

    phuang@mdanderson.org

    Affiliation: Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

    X
  • Published: May 08, 2012
  • DOI: 10.1371/journal.pbio.1001326

About the Authors

Weiqin Lu, Yumin Hu, Gang Chen, Zhao Chen, Hui Zhang, Feng Wang, Li Feng, Helene Pelicano, Peng Huang
Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Yumin Hu, Feng Wang
State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou, China
Hua Wang
Department of GI Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Michael J. Keating
Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Jinsong Liu, Huamin Wang
Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
Wallace McKeehan, Yongde Luo
Proteomics and Nanotechnology Laboratory, Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas, United States of America,

Corresponding Author

Email: phuang@mdanderson.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: WL PH . Performed the experiments: WL YH GC ZC HZ FW LF HP HW HW YL. Analyzed the data: WL YH GC HW HW YL. Contributed reagents/materials/analysis tools: WL JL MK WM YL. Wrote the paper: HP WL YH.