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Research Article

Sialyllactose in Viral Membrane Gangliosides Is a Novel Molecular Recognition Pattern for Mature Dendritic Cell Capture of HIV-1

  • Nuria Izquierdo-Useros equal contributor mail,

    equal contributor Contributed equally to this work with: Nuria Izquierdo-Useros, Maier Lorizate

    nizquierdo@irsicaixa.es (NI-U); maier.lorizate@med.uni-heidelberg.de (ML); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

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  • Maier Lorizate equal contributor mail,

    equal contributor Contributed equally to this work with: Nuria Izquierdo-Useros, Maier Lorizate

    nizquierdo@irsicaixa.es (NI-U); maier.lorizate@med.uni-heidelberg.de (ML); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

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  • F.-Xabier Contreras ,

    Affiliation: Heidelberg University Biochemistry Center (BZH), Heidelberg

    F-XC and MTR-P also contributed equally to this work. H-GK and JM-P are joint senior authors on this work.

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  • Maria T. Rodriguez-Plata ,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

    F-XC and MTR-P also contributed equally to this work. H-GK and JM-P are joint senior authors on this work.

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  • Bärbel Glass,

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

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  • Itziar Erkizia,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

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  • Julia G. Prado,

    Affiliation: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain

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  • Josefina Casas,

    Affiliation: Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain

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  • Gemma Fabriàs,

    Affiliation: Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain

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  • Hans-Georg Kräusslich mail,

    nizquierdo@irsicaixa.es (NI-U); maier.lorizate@med.uni-heidelberg.de (ML); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliation: Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany

    F-XC and MTR-P also contributed equally to this work. H-GK and JM-P are joint senior authors on this work.

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  • Javier Martinez-Picado mail

    nizquierdo@irsicaixa.es (NI-U); maier.lorizate@med.uni-heidelberg.de (ML); hans-georg.kraeusslich@med.uni-heidelberg.de (H-GK); jmpicado@irsicaixa.es (JM-P)

    Affiliations: AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

    F-XC and MTR-P also contributed equally to this work. H-GK and JM-P are joint senior authors on this work.

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  • Published: April 24, 2012
  • DOI: 10.1371/journal.pbio.1001315

About the Authors

Nuria Izquierdo-Useros, Maria T. Rodriguez-Plata, Itziar Erkizia, Julia G. Prado, Javier Martinez-Picado
AIDS Research Institute IrsiCaixa, Institut d'Investigació en Ciències de la Salut Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain
Maier Lorizate, Bärbel Glass, Hans-Georg Kräusslich
Department of Infectious Diseases, Virology, Universitätsklinikum Heidelberg, Heidelberg, Germany
F.-Xabier Contreras
Heidelberg University Biochemistry Center (BZH), Heidelberg
Josefina Casas, Gemma Fabriàs
Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC)/CSIC, Barcelona, Spain
Javier Martinez-Picado
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain

Corresponding Authors

Competing Interests

A patent application based on this work has been filed (EP11382392.6, 2011). The authors have declared that no other competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: NI-U ML JM-P H-GK. Performed the experiments: NI-U ML F-XC MTR-P BG IE JC GF. Analyzed the data: NI-U ML F-XC MTR-P JC GF. Contributed reagents/materials/analysis tools: JGP. Wrote the paper: NI-U ML F-XC JM-P H-GK.