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Research Article

Development and Function of Invariant Natural Killer T Cells Producing TH2- and TH17-Cytokines

  • Hiroshi Watarai mail,

    hwatarai@rcai.riken.jp

    Affiliations: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan, PRESTO, Japan Science and Technology Agency, Tokyo, Japan

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  • Etsuko Sekine-Kondo,

    Affiliation: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Tomokuni Shigeura,

    Affiliation: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Yasutaka Motomura,

    Affiliation: Division of Biotechnology, Research Institute for Biological Science, Tokyo University of Science, Chiba, Japan

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  • Takuwa Yasuda,

    Affiliation: Laboratory for Immunogenetics, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Rumi Satoh,

    Affiliation: Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Hisahiro Yoshida,

    Affiliation: Laboratory for Immunogenetics, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Masato Kubo,

    Affiliation: Division of Biotechnology, Research Institute for Biological Science, Tokyo University of Science, Chiba, Japan

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  • Hiroshi Kawamoto,

    Affiliation: Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Haruhiko Koseki,

    Affiliation: Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Masaru Taniguchi

    Affiliation: Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

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  • Published: February 07, 2012
  • DOI: 10.1371/journal.pbio.1001255

About the Authors

Hiroshi Watarai, Etsuko Sekine-Kondo, Tomokuni Shigeura, Masaru Taniguchi
Laboratory for Immune Regulation, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
Hiroshi Watarai
PRESTO, Japan Science and Technology Agency, Tokyo, Japan
Yasutaka Motomura, Masato Kubo
Division of Biotechnology, Research Institute for Biological Science, Tokyo University of Science, Chiba, Japan
Takuwa Yasuda, Hisahiro Yoshida
Laboratory for Immunogenetics, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
Rumi Satoh, Hiroshi Kawamoto
Laboratory for Lymphocyte Development, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan
Haruhiko Koseki
Laboratory for Developmental Genetics, RIKEN Research Center for Allergy and Immunology, Kanagawa, Japan

Corresponding Author

Email: hwatarai@rcai.riken.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HW. Performed the experiments: HW ESK TS RS. Analyzed the data: HW. Contributed reagents/materials/analysis tools: Provided E4bp4-deficient mice: YM MK. Provided Il15-mutant mice: TY HY. Wrote the paper: HW MT. Built the initial constructs, generated mouse lines of Il17rb-deficient mice: HW. Designed FTOC experiments: HKawamoto. Generated Il17rb-deficient embryonic stem cell lines: HKoseki. Supervised the project: MT.