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Research Article

Pulsed Feedback Defers Cellular Differentiation

  • Joe H. Levine,

    Affiliation: Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America

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  • Michelle E. Fontes,

    Affiliation: Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America

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  • Jonathan Dworkin,

    Affiliation: Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

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  • Michael B. Elowitz mail

    melowitz@caltech.edu

    Affiliation: Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America

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  • Published: January 31, 2012
  • DOI: 10.1371/journal.pbio.1001252

About the Authors

Joe H. Levine, Michelle E. Fontes, Michael B. Elowitz
Howard Hughes Medical Institute and Division of Biology and Department of Applied Physics, California Institute of Technology, Pasadena, California, United States of America
Jonathan Dworkin
Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York, New York, United States of America

Corresponding Author

Email: melowitz@caltech.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JHL MBE JD. Performed the experiments: JHL MEF. Analyzed the data: JHL MBE. Contributed reagents/materials/analysis tools: JHL MEF MBE. Wrote the paper: JHL MBE.