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Research Article

Substrate Specificity within a Family of Outer Membrane Carboxylate Channels

  • Elif Eren,

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Jagamya Vijayaraghavan,

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Jiaming Liu,

    Affiliation: Syracuse University, Department of Physics, Syracuse, New York, United States of America

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  • Belete R. Cheneke,

    Affiliation: Syracuse University, Department of Physics, Syracuse, New York, United States of America

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  • Debra S. Touw,

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Bryan W. Lepore,

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Mridhu Indic,

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Liviu Movileanu,

    Affiliation: Syracuse University, Department of Physics, Syracuse, New York, United States of America

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  • Bert van den Berg mail

    bert.vandenberg@umassmed.edu

    Affiliation: University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America

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  • Published: January 17, 2012
  • DOI: 10.1371/journal.pbio.1001242

About the Authors

Elif Eren, Jagamya Vijayaraghavan, Debra S. Touw, Bryan W. Lepore, Mridhu Indic, Bert van den Berg
University of Massachusetts Medical School, Program in Molecular Medicine, Worcester, Massachusetts, United States of America
Jiaming Liu, Belete R. Cheneke, Liviu Movileanu
Syracuse University, Department of Physics, Syracuse, New York, United States of America

Corresponding Author

Email: bert.vandenberg@umassmed.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LM BvB. Performed the experiments: EE JV JL BRC BWL DST MI BvB. Analyzed the data: EE LM BvB. Contributed reagents/materials/analysis tools: EE JL BRC DST MI BvB. Wrote the paper: EE BvB. Cloned, purified and crystallized proteins: EE JV MI BvB. Carried out transport experiments: EE BWL DST. Determined crystal structures: EE DST BvB. Performed single channel experiments: JL BRC.