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Research Article

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

  • Ruohan Xia,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Hongge Jia,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Junkai Fan,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Yajuan Liu,

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Jianhang Jia mail

    Jianhang.jia@uky.edu

    Affiliation: Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

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  • Published: January 10, 2012
  • DOI: 10.1371/journal.pbio.1001238

About the Authors

Ruohan Xia, Hongge Jia, Junkai Fan, Yajuan Liu, Jianhang Jia
Department of Molecular and Cellular Biochemistry, Markey Cancer Center, University of Kentucky, Lexington, Kentucky, United States of America

Corresponding Author

Email: Jianhang.jia@uky.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: RX JJ. Performed the experiments: RX HJ JF YL. Analyzed the data: RX JJ. Wrote the paper: JJ.