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Research Article

Recognition and Degradation of Plant Cell Wall Polysaccharides by Two Human Gut Symbionts

  • Eric C. Martens equal contributor mail,

    equal contributor Contributed equally to this work with: Eric C. Martens, Elisabeth C. Lowe

    emartens@umich.edu (ECM); david.bolam@newcastle.ac.uk (DNB)

    Affiliations: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America, Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Elisabeth C. Lowe equal contributor,

    equal contributor Contributed equally to this work with: Eric C. Martens, Elisabeth C. Lowe

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

    X
  • Herbert Chiang,

    Affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Nicholas A. Pudlo,

    Affiliation: Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America

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  • Meng Wu,

    Affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Nathan P. McNulty,

    Affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • D. Wade Abbott,

    Affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America

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  • Bernard Henrissat,

    Affiliation: Architecture et Fonction des Macromolécules Biologiques, CNRS and Universities of Aix-Marseille I & II, Marseille, France

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  • Harry J. Gilbert,

    Affiliations: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom, Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America

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  • David N. Bolam mail,

    emartens@umich.edu (ECM); david.bolam@newcastle.ac.uk (DNB)

    Affiliation: Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

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  • Jeffrey I. Gordon

    Affiliation: Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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  • Published: December 20, 2011
  • DOI: 10.1371/journal.pbio.1001221

About the Authors

Eric C. Martens, Herbert Chiang, Meng Wu, Nathan P. McNulty, Jeffrey I. Gordon
Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, United States of America
Eric C. Martens, Nicholas A. Pudlo
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
Elisabeth C. Lowe, Harry J. Gilbert, David N. Bolam
Institute for Cell and Molecular Biosciences, The Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom
D. Wade Abbott, Harry J. Gilbert
Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia, United States of America
Bernard Henrissat
Architecture et Fonction des Macromolécules Biologiques, CNRS and Universities of Aix-Marseille I & II, Marseille, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ECM ECL DNB JIG. Performed the experiments: ECM ECL HC NAP MW. Analyzed the data: ECM ECL NAP MW BH DNB. Contributed reagents/materials/analysis tools: ECM ECL DWA HC MW NPM BH DNB. Wrote the paper: ECM ECL DWA BH HJG DNB JIG.