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Research Article

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

  • Andréa M. Caricilli,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Paty K. Picardi,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Lélia L. de Abreu,

    Affiliation: Department of Nursing, State University of Campinas, Campinas, Brazil

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  • Mirian Ueno,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Patrícia O. Prada,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Eduardo R. Ropelle,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Sandro Massao Hirabara,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Ângela Castoldi,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Pedro Vieira,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Niels O. S. Camara,

    Affiliation: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • Rui Curi,

    Affiliation: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

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  • José B. Carvalheira,

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Mário J. A. Saad mail

    msaad@fcm.unicamp.br

    Affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil

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  • Published: December 06, 2011
  • DOI: 10.1371/journal.pbio.1001212

About the Authors

Andréa M. Caricilli, Paty K. Picardi, Mirian Ueno, Patrícia O. Prada, Eduardo R. Ropelle, José B. Carvalheira, Mário J. A. Saad
Department of Internal Medicine, State University of Campinas, Campinas, Brazil
Lélia L. de Abreu
Department of Nursing, State University of Campinas, Campinas, Brazil
Sandro Massao Hirabara, Rui Curi
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
Ângela Castoldi, Pedro Vieira, Niels O. S. Camara
Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil

Corresponding Author

Email: msaad@fcm.unicamp.br

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: AC MS. Performed the experiments: AC PKP LLA ER MU PP SH AC PV NOSC. Analyzed the data: AC MS JBC. Contributed reagents/materials/analysis tools: RC NOSC JBC MS. Wrote the paper: AC MS.