Advertisement
Research Article

Electrostatically Biased Binding of Kinesin to Microtubules

  • Barry J. Grant equal contributor,

    equal contributor Contributed equally to this work with: Barry J. Grant, Dana M. Gheorghe

    Affiliation: Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America

    Current address: Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America

    X
  • Dana M. Gheorghe equal contributor,

    equal contributor Contributed equally to this work with: Barry J. Grant, Dana M. Gheorghe

    Affiliation: Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, United Kingdom

    X
  • Wenjun Zheng,

    Affiliation: Department of Physics, University at Buffalo, Buffalo, New York, United States of America

    X
  • Maria Alonso,

    Affiliation: Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, United Kingdom

    X
  • Gary Huber,

    Affiliation: Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America

    X
  • Maciej Dlugosz,

    Affiliation: Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland

    X
  • J. Andrew McCammon mail,

    jmccammon@mccammon.ucsd.edu (JAM) (JM); r.a.cross@warwick.ac.uk (RAC) (RC)

    Affiliations: Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America, Department of Pharmacology, University of California–San Diego, La Jolla, California, United States of America

    These authors are joint senior authors on this work.

    X
  • Robert A. Cross mail

    jmccammon@mccammon.ucsd.edu (JAM) (JM); r.a.cross@warwick.ac.uk (RAC) (RC)

    Affiliation: Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, United Kingdom

    These authors are joint senior authors on this work.

    X
  • Published: November 29, 2011
  • DOI: 10.1371/journal.pbio.1001207

About the Authors

Barry J. Grant, Gary Huber, J. Andrew McCammon
Department of Chemistry and Biochemistry, Center for Theoretical Biological Physics and Howard Hughes Medical Institute, University of California–San Diego, La Jolla, California, United States of America
Dana M. Gheorghe, Maria Alonso, Robert A. Cross
Centre for Mechanochemical Cell Biology, Warwick Medical School, University of Warwick, Coventry, United Kingdom
Wenjun Zheng
Department of Physics, University at Buffalo, Buffalo, New York, United States of America
Maciej Dlugosz
Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw, Warsaw, Poland
J. Andrew McCammon
Department of Pharmacology, University of California–San Diego, La Jolla, California, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BJG DG WZ RAC JAM. Performed the experiments: BJG DG. Analyzed the data: BJG DG MD GH. Contributed reagents/materials/analysis tools: MA. Wrote the paper: BJG RAC.