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Research Article

Molecular Pathogenesis of EBV Susceptibility in XLP as Revealed by Analysis of Female Carriers with Heterozygous Expression of SAP

  • Umaimainthan Palendira,

    Affiliations: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia, St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia

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  • Carol Low,

    Affiliation: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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  • Anna Chan,

    Affiliation: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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  • Andrew D. Hislop,

    Affiliation: School of Cancer Sciences and MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, United Kingdom

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  • Edwin Ho,

    Affiliation: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia

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  • Tri Giang Phan,

    Affiliations: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia, St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia

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  • Elissa Deenick,

    Affiliations: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia, St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia

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  • Matthew C. Cook,

    Affiliations: Australian National University Medical School, Canberra, Australian Capital Territory, Australia, John Curtin School of Medical Research, Canberra, Australian Capital Territory, Australia, Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia

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  • D. Sean Riminton,

    Affiliation: Department of Immunology, Concord Hospital, Sydney, New South Wales, Australia

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  • Sharon Choo,

    Affiliation: Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia

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  • Richard Loh,

    Affiliation: Department of Clinical Immunology, Princess Margaret Hospital for Children, Perth, Western Australia, Australia

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  • Frank Alvaro,

    Affiliation: Pediatric Hematology, John Hunter Hospital, Newcastle, New South Wales, Australia

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  • Claire Booth,

    Affiliation: Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom

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  • H. Bobby Gaspar,

    Affiliation: Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom

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  • Alessandro Moretta,

    Affiliation: Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy

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  • Rajiv Khanna,

    Affiliation: Tumour Immunology Laboratory, Division of Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

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  • Alan B. Rickinson,

    Affiliation: School of Cancer Sciences and MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, United Kingdom

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  • Stuart G. Tangye mail

    s.tangye@garvan.org.au

    Affiliations: Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia, St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia

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  • Published: November 01, 2011
  • DOI: 10.1371/journal.pbio.1001187

About the Authors

Umaimainthan Palendira, Carol Low, Anna Chan, Edwin Ho, Tri Giang Phan, Elissa Deenick, Stuart G. Tangye
Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia
Umaimainthan Palendira, Tri Giang Phan, Elissa Deenick, Stuart G. Tangye
St. Vincent's Clinical School, University of New South Wales, Darlinghurst, New South Wales, Australia
Andrew D. Hislop, Alan B. Rickinson
School of Cancer Sciences and MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, United Kingdom
Matthew C. Cook
Australian National University Medical School, Canberra, Australian Capital Territory, Australia
Matthew C. Cook
John Curtin School of Medical Research, Canberra, Australian Capital Territory, Australia
Matthew C. Cook
Department of Immunology, Canberra Hospital, Canberra, Australian Capital Territory, Australia
D. Sean Riminton
Department of Immunology, Concord Hospital, Sydney, New South Wales, Australia
Sharon Choo
Department of Allergy and Immunology, Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia
Richard Loh
Department of Clinical Immunology, Princess Margaret Hospital for Children, Perth, Western Australia, Australia
Frank Alvaro
Pediatric Hematology, John Hunter Hospital, Newcastle, New South Wales, Australia
Claire Booth, H. Bobby Gaspar
Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, United Kingdom
Alessandro Moretta
Dipartimento di Medicina Sperimentale, Università di Genova, Genova, Italy
Rajiv Khanna
Tumour Immunology Laboratory, Division of Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia

Corresponding Author

Email: s.tangye@garvan.org.au

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: UP SGT. Performed the experiments: UP CL AC EH TGP EKD. Analyzed the data: UP CL AC EH TGP EKD. Contributed reagents/materials/analysis tools: ADH ABR RK AM. Wrote the paper: UP SGT. Provided clinical samples: MCC DSR SC RL CB HBG FA.