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Research Article

Mesenchymal Transition and Dissemination of Cancer Cells Is Driven by Myeloid-Derived Suppressor Cells Infiltrating the Primary Tumor

  • Benjamin Toh,

    Affiliation: Singapore Immunology Network, BMSI, A-STAR, Singapore

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  • Xiaojie Wang,

    Affiliation: Singapore Immunology Network, BMSI, A-STAR, Singapore

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  • Jo Keeble,

    Affiliation: Singapore Immunology Network, BMSI, A-STAR, Singapore

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  • Wen Jing Sim,

    Affiliation: Institute for Molecular and Cellular Biology, BMSI, A-STAR, Singapore

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  • Karen Khoo,

    Affiliation: Singapore Immunology Network, BMSI, A-STAR, Singapore

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  • Wing-Cheong Wong,

    Affiliation: Bioinformatics Institute, BMSI, A-STAR, Singapore

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  • Masashi Kato,

    Affiliation: College of Life and Health Sciences, Chubu University, Aichi, Japan

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  • Armelle Prevost-Blondel,

    Affiliation: Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France

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  • Jean-Paul Thiery,

    Affiliations: Institute for Molecular and Cellular Biology, BMSI, A-STAR, Singapore, Cancer Science Institute, National University of Singapore, Singapore

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  • Jean-Pierre Abastado mail

    abastado@immunol.a-star.edu.sg

    Affiliation: Singapore Immunology Network, BMSI, A-STAR, Singapore

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  • Published: September 27, 2011
  • DOI: 10.1371/journal.pbio.1001162

About the Authors

Benjamin Toh, Xiaojie Wang, Jo Keeble, Karen Khoo, Jean-Pierre Abastado
Singapore Immunology Network, BMSI, A-STAR, Singapore
Wen Jing Sim, Jean-Paul Thiery
Institute for Molecular and Cellular Biology, BMSI, A-STAR, Singapore
Wing-Cheong Wong
Bioinformatics Institute, BMSI, A-STAR, Singapore
Masashi Kato
College of Life and Health Sciences, Chubu University, Aichi, Japan
Armelle Prevost-Blondel
Institut Cochin, Université Paris Descartes, CNRS UMR 8104, Paris, France
Jean-Paul Thiery
Cancer Science Institute, National University of Singapore, Singapore

Corresponding Author

Email: abastado@immunol.a-star.edu.sg

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: BT JK JPT JPA. Performed the experiments: BT XW JK WJS KK. Analyzed the data: BT JK KK WCW JPT JPA. Contributed reagents/materials/analysis tools: MK APB. Wrote the paper: BT JPA.