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Research Article

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

  • Gregory D. Rak,

    Affiliations: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Emily M. Mace,

    Affiliation: Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Pinaki P. Banerjee,

    Affiliation: Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Tatyana Svitkina,

    Affiliation: Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Jordan S. Orange mail

    orange@upenn.edu

    Affiliations: University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Published: September 13, 2011
  • DOI: 10.1371/journal.pbio.1001151

About the Authors

Gregory D. Rak, Jordan S. Orange
University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Gregory D. Rak, Emily M. Mace, Pinaki P. Banerjee, Jordan S. Orange
Children's Hospital of Philadelphia Research Institute, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Tatyana Svitkina
Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: orange@upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GDR TS JSO. Performed the experiments: GDR EMM PPB. Analyzed the data: GDR EMM PPB JSO. Contributed reagents/materials/analysis tools: TS. Wrote the paper: GDR JSO.