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Research Article

CD81 Is Essential for the Re-entry of Hematopoietic Stem Cells to Quiescence following Stress-Induced Proliferation Via Deactivation of the Akt Pathway

  • Kuanyin K. Lin,

    Affiliations: Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America, Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Lara Rossi,

    Affiliations: Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America, Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America, Institute of Hematology and Medical Oncology “L. & A. Seràgnoli,” University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy

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  • Nathan C. Boles,

    Affiliations: Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America, Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America

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  • Brian E. Hall,

    Affiliation: Amnis Corporation, Seattle, Washington, United States of America

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  • Thaddeus C. George,

    Affiliation: Amnis Corporation, Seattle, Washington, United States of America

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  • Margaret A. Goodell mail

    goodell@bcm.edu

    Affiliations: Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America, Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

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  • Published: September 13, 2011
  • DOI: 10.1371/journal.pbio.1001148

About the Authors

Kuanyin K. Lin, Margaret A. Goodell
Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, United States of America
Kuanyin K. Lin, Lara Rossi, Nathan C. Boles, Margaret A. Goodell
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas, United States of America
Kuanyin K. Lin, Lara Rossi, Nathan C. Boles, Margaret A. Goodell
Stem Cell and Regenerative Medicine Center, Baylor College of Medicine, Houston, Texas, United States of America
Lara Rossi
Institute of Hematology and Medical Oncology “L. & A. Seràgnoli,” University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy
Brian E. Hall, Thaddeus C. George
Amnis Corporation, Seattle, Washington, United States of America
Margaret A. Goodell
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America

Corresponding Author

Email: goodell@bcm.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: KKL. Performed the experiments: KKL LR NCB BH TG. Analyzed the data: KKL LR NCB BH TG. Wrote the paper: KKL MAG.