Advertisement
Research Article

Functional Dissection of the Proton Pumping Modules of Mitochondrial Complex I

  • Stefan Dröse equal contributor,

    equal contributor Contributed equally to this work with: Stefan Dröse, Stephanie Krack

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Stephanie Krack equal contributor,

    equal contributor Contributed equally to this work with: Stefan Dröse, Stephanie Krack

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Lucie Sokolova,

    Affiliations: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany, Institute of Physical and Theoretical Chemistry, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Klaus Zwicker,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Hans-Dieter Barth,

    Affiliation: Institute of Physical and Theoretical Chemistry, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Nina Morgner,

    Affiliation: Institute of Physical and Theoretical Chemistry, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Heinrich Heide,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Mirco Steger,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Esther Nübel,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Volker Zickermann,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Stefan Kerscher,

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Bernhard Brutschy,

    Affiliation: Institute of Physical and Theoretical Chemistry, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Michael Radermacher,

    Affiliation: University of Vermont, College of Medicine, Department of Molecular Physiology and Biophysics, Burlington, Vermont, United States of America

    X
  • Ulrich Brandt mail

    brandt@zbc.kgu.de

    Affiliation: Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany

    X
  • Published: August 23, 2011
  • DOI: 10.1371/journal.pbio.1001128

About the Authors

Stefan Dröse, Stephanie Krack, Lucie Sokolova, Klaus Zwicker, Heinrich Heide, Mirco Steger, Esther Nübel, Volker Zickermann, Stefan Kerscher, Ulrich Brandt
Molecular Bioenergetics Group, Medical School, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Center for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany
Lucie Sokolova, Hans-Dieter Barth, Nina Morgner, Bernhard Brutschy
Institute of Physical and Theoretical Chemistry, Cluster of Excellence Frankfurt “Macromolecular Complexes,” Centre for Membrane Proteomics, Johann Wolfgang Goethe-Universität, Frankfurt, Germany
Michael Radermacher
University of Vermont, College of Medicine, Department of Molecular Physiology and Biophysics, Burlington, Vermont, United States of America

Corresponding Author

Email: brandt@zbc.kgu.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: UB SD SKe BB MR. Performed the experiments: SKr SKe LS NM HDB HH EN KZ MS MR. Analyzed the data: UB SD SKr HH KZ MR BB. Contributed reagents/materials/analysis tools: VZ. Wrote the paper: UB SD MR.