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Research Article

A Novel Sperm-Delivered Toxin Causes Late-Stage Embryo Lethality and Transmission Ratio Distortion in C. elegans

  • Hannah S. Seidel mail,

    hsseidel@wisc.edu (HSS); leonid@genomics.princeton.edu (LK)

    Affiliations: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America

    Current address: Department of Biochemistry, University of Wisconsin–Madison, Madison, Wisconsin, United States of America

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  • Michael Ailion,

    Affiliation: Department of Biology, University of Utah, Salt Lake City, Utah, United States of America

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  • Jialing Li,

    Affiliation: Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Alexander van Oudenaarden,

    Affiliations: Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Matthew V. Rockman,

    Affiliations: Department of Biology, New York University, New York, New York, United States of America, Center for Genomics and Systems Biology, New York University, New York, New York, United States of America

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  • Leonid Kruglyak mail

    hsseidel@wisc.edu (HSS); leonid@genomics.princeton.edu (LK)

    Affiliations: Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America, Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

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  • Published: July 26, 2011
  • DOI: 10.1371/journal.pbio.1001115

About the Authors

Hannah S. Seidel, Leonid Kruglyak
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
Hannah S. Seidel, Leonid Kruglyak
Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
Michael Ailion
Department of Biology, University of Utah, Salt Lake City, Utah, United States of America
Jialing Li, Alexander van Oudenaarden
Department of Physics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Alexander van Oudenaarden
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Matthew V. Rockman
Department of Biology, New York University, New York, New York, United States of America
Matthew V. Rockman
Center for Genomics and Systems Biology, New York University, New York, New York, United States of America
Leonid Kruglyak
Howard Hughes Medical Institute, Chevy Chase, Maryland, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: HSS MA MVR LK. Performed the experiments: HSS MA JL MVR. Analyzed the data: HSS MA. Contributed reagents/materials/analysis tools: HSS MA JL AO. Wrote the paper: HSS, with input from MA MVR LK.