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Research Article

Synaptic Transmission from Horizontal Cells to Cones Is Impaired by Loss of Connexin Hemichannels

  • Lauw J. Klaassen,

    Affiliation: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Ziyi Sun,

    Affiliation: Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Marvin N. Steijaert,

    Affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

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  • Petra Bolte,

    Affiliation: Department of Neurobiology, University of Oldenburg, Oldenburg, Germany

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  • Iris Fahrenfort,

    Affiliation: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Trijntje Sjoerdsma,

    Affiliation: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Jan Klooster,

    Affiliation: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Yvonne Claassen,

    Affiliation: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands

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  • Colleen R. Shields,

    Affiliations: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands, Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, New York, United States of America

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  • Huub M. M. Ten Eikelder,

    Affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands

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  • Ulrike Janssen-Bienhold,

    Affiliation: Department of Neurobiology, University of Oldenburg, Oldenburg, Germany

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  • Georg Zoidl,

    Affiliations: Department of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany, Department of Cytology, Ruhr University, Bochum, Germany

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  • Douglas G. McMahon,

    Affiliation: Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America

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  • Maarten Kamermans mail

    m.kamermans@nin.knaw.nl

    Affiliations: Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands, Department of Neurogenetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

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  • Published: July 19, 2011
  • DOI: 10.1371/journal.pbio.1001107

About the Authors

Lauw J. Klaassen, Iris Fahrenfort, Trijntje Sjoerdsma, Jan Klooster, Yvonne Claassen, Colleen R. Shields, Maarten Kamermans
Research Unit Retinal Signal Processing, The Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
Ziyi Sun, Douglas G. McMahon
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America
Marvin N. Steijaert, Huub M. M. Ten Eikelder
Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
Petra Bolte, Ulrike Janssen-Bienhold
Department of Neurobiology, University of Oldenburg, Oldenburg, Germany
Colleen R. Shields
Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, New York, United States of America
Georg Zoidl
Department of Neuroanatomy and Molecular Brain Research, Ruhr University, Bochum, Germany
Georg Zoidl
Department of Cytology, Ruhr University, Bochum, Germany
Maarten Kamermans
Department of Neurogenetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

Corresponding Author

Email: m.kamermans@nin.knaw.nl

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MK DM GZ UJB HMMTE. Performed the experiments: LJK ZS MNS PB IF TS JK YC CS. Analyzed the data: LK ZS MNS PB IF TS JK YC CS MK GZ UJB. Wrote the paper: MK LK GZ UJB DM.