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Research Article

Defining the Specificity of Cotranslationally Acting Chaperones by Systematic Analysis of mRNAs Associated with Ribosome-Nascent Chain Complexes

  • Marta del Alamo,

    Affiliation: Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America

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  • Daniel J. Hogan,

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Sebastian Pechmann,

    Affiliation: Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America

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  • Veronique Albanese,

    Affiliation: Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America

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  • Patrick O. Brown,

    Affiliations: Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

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  • Judith Frydman mail

    jfrydman@stanford.edu

    Affiliation: Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America

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  • Published: July 12, 2011
  • DOI: 10.1371/journal.pbio.1001100

About the Authors

Marta del Alamo, Sebastian Pechmann, Veronique Albanese, Judith Frydman
Department of Biology and BioX Program, Stanford University, Stanford, California, United States of America
Daniel J. Hogan, Patrick O. Brown
Department of Biochemistry, Stanford University School of Medicine, Stanford, California, United States of America
Daniel J. Hogan, Patrick O. Brown
Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California, United States of America

Corresponding Author

Email: jfrydman@stanford.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JF MdA. Performed the experiments: MdA. Analyzed the data: MdA DJH SP POB JF. Contributed reagents/materials/analysis tools: VA SP. Wrote the paper: MdA JF POB DJH. Edited the manuscript: VA SP DJH POB.