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Research Article

Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells

  • Guangming Wu equal contributor,

    equal contributor Contributed equally to this work with: Guangming Wu, Na Liu

    Affiliation: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany

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  • Na Liu equal contributor,

    equal contributor Contributed equally to this work with: Guangming Wu, Na Liu

    Affiliations: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany, Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany

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  • Ina Rittelmeyer,

    Affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, and TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

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  • Amar Deep Sharma,

    Affiliation: Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany

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  • Malte Sgodda,

    Affiliation: Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany

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  • Holm Zaehres,

    Affiliation: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany

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  • Martina Bleidißel,

    Affiliation: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany

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  • Boris Greber,

    Affiliation: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany

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  • Luca Gentile,

    Affiliation: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany

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  • Dong Wook Han,

    Affiliations: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany, Department of Stem Cell Biology, Konkuk University, Seoul, Republic of Korea

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  • Cornelia Rudolph,

    Affiliation: Junior Research Group Genetic & Epigenetic Integrity, Cluster of Excellence REBIRTH, Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

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  • Doris Steinemann,

    Affiliation: Junior Research Group Genetic & Epigenetic Integrity, Cluster of Excellence REBIRTH, Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany

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  • Axel Schambach,

    Affiliation: Junior Research Group Hematopoietic Cell Therapy, Cluster of Excellence REBIRTH, Department Experimental Hematology, Hannover Medical School, Hannover, Germany

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  • Michael Ott,

    Affiliation: Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, and TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany

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  • Hans R. Schöler,

    Affiliations: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany, Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany, Medical Faculty, University of Münster, Münster, Germany

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  • Tobias Cantz mail

    cantz.tobias@mh-hannover.de

    Affiliations: Max-Planck-Institute for Molecular Biomedicine, Münster, Germany, Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany

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  • Published: July 12, 2011
  • DOI: 10.1371/journal.pbio.1001099

About the Authors

Guangming Wu, Na Liu, Holm Zaehres, Martina Bleidißel, Boris Greber, Luca Gentile, Dong Wook Han, Hans R. Schöler, Tobias Cantz
Max-Planck-Institute for Molecular Biomedicine, Münster, Germany
Na Liu, Amar Deep Sharma, Malte Sgodda, Hans R. Schöler, Tobias Cantz
Junior Research Group Stem Cell Biology, Cluster of Excellence REBIRTH, Hannover Medical School, Hannover, Germany
Ina Rittelmeyer, Michael Ott
Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, and TWINCORE Centre for Experimental and Clinical Infection Research, Hannover, Germany
Dong Wook Han
Department of Stem Cell Biology, Konkuk University, Seoul, Republic of Korea
Cornelia Rudolph, Doris Steinemann
Junior Research Group Genetic & Epigenetic Integrity, Cluster of Excellence REBIRTH, Institute of Cell and Molecular Pathology, Hannover Medical School, Hannover, Germany
Axel Schambach
Junior Research Group Hematopoietic Cell Therapy, Cluster of Excellence REBIRTH, Department Experimental Hematology, Hannover Medical School, Hannover, Germany
Hans R. Schöler
Medical Faculty, University of Münster, Münster, Germany

Corresponding Author

Email: cantz.tobias@mh-hannover.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GMW NL AS HRS TC. Performed the experiments: GMW NL IR ADS MS BG LG DWH CR DS. Analyzed the data: GMW NL IR BG LG DWH CR DS TC. Contributed reagents/materials/analysis tools: ADS MS HZ MB MO. Wrote the paper: GMW AS MO HRS TC.