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Research Article

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

  • Yongbin Chen,

    Affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Noriaki Sasai,

    Affiliation: MRC-National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Guoqiang Ma,

    Affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Tao Yue,

    Affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Jianhang Jia,

    Affiliation: Markey Cancer Center and Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

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  • James Briscoe,

    Affiliation: MRC-National Institute for Medical Research, Mill Hill, London, United Kingdom

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  • Jin Jiang mail

    jin.jiang@utsouthwestern.edu

    Affiliation: Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Published: June 14, 2011
  • DOI: 10.1371/journal.pbio.1001083

About the Authors

Yongbin Chen, Guoqiang Ma, Tao Yue, Jin Jiang
Department of Developmental Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Noriaki Sasai, James Briscoe
MRC-National Institute for Medical Research, Mill Hill, London, United Kingdom
Jianhang Jia
Markey Cancer Center and Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America

Corresponding Author

Email: jin.jiang@utsouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: Y Chen, J Briscoe, J Jiang. Performed the experiments: Y Chen, N Sasai, G Ma, T Yue. Analyzed the data: Y Chen, N Sasai, J Briscoe, J Jiang. Contributed reagents/materials/analysis tools: J Jia, T Yue. Wrote the paper: J Jiang, J Briscoe, Y Chen.