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Research Article

Towards a Pharmacophore for Amyloid

  • Meytal Landau,

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Michael R. Sawaya,

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Kym F. Faull,

    Affiliation: The Pasarow Mass Spectrometry Laboratory, The NPI-Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

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  • Arthur Laganowsky,

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Lin Jiang,

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Stuart A. Sievers,

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Jie Liu,

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

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  • Jorge R. Barrio,

    Affiliation: Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

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  • David Eisenberg mail

    david@mbi.ucla.edu

    Affiliation: Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America

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  • Published: June 14, 2011
  • DOI: 10.1371/journal.pbio.1001080

About the Authors

Meytal Landau, Michael R. Sawaya, Arthur Laganowsky, Lin Jiang, Stuart A. Sievers, David Eisenberg
Howard Hughes Medical Institute, UCLA-DOE Institute for Genomics and Proteomics, Departments of Biological Chemistry and Chemistry and Biochemistry, University of California, Los Angeles, California, United States of America
Kym F. Faull
The Pasarow Mass Spectrometry Laboratory, The NPI-Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America
Jie Liu, Jorge R. Barrio
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California, United States of America

Corresponding Author

Email: david@mbi.ucla.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ML DE. Performed the experiments: ML KFF. Analyzed the data: ML MRS. Contributed reagents/materials/analysis tools: LJ AL SAS JL JRB. Wrote the paper: ML DE. Contributed helpful discussions: AL SAS JRB.