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Research Article

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

  • Shulin Ju,

    Affiliations: Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Daniel F. Tardiff,

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Haesun Han,

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Kanneganti Divya,

    Affiliation: Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America

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  • Quan Zhong,

    Affiliations: Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Lynne E. Maquat,

    Affiliation: Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America

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  • Daryl A. Bosco,

    Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Lawrence J. Hayward,

    Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Robert H. Brown Jr.,

    Affiliation: Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

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  • Susan Lindquist,

    Affiliations: Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America, Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Dagmar Ringe mail,

    ringe@brandeis.edu (DR); petsko@brandeis.edu (GAP)

    Affiliations: Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Gregory A. Petsko mail

    ringe@brandeis.edu (DR); petsko@brandeis.edu (GAP)

    Affiliations: Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America, Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America

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  • Published: April 26, 2011
  • DOI: 10.1371/journal.pbio.1001052

About the Authors

Shulin Ju, Kanneganti Divya, Dagmar Ringe, Gregory A. Petsko
Department of Biochemistry and Chemistry, Rosenstiel Basic Medical Sciences Research Center, Brandeis University, Waltham, Massachusetts, United States of America
Shulin Ju, Dagmar Ringe, Gregory A. Petsko
Department of Neurology and Center for Neurologic Diseases, Harvard Medical School and Brigham & Women's Hospital, Cambridge, Massachusetts, United States of America
Daniel F. Tardiff, Haesun Han, Susan Lindquist
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, United States of America
Daniel F. Tardiff, Haesun Han, Susan Lindquist
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Quan Zhong
Department of Cancer Biology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
Quan Zhong
Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
Lynne E. Maquat
Department of Biochemistry and Biophysics and Center for RNA Biology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, United States of America
Daryl A. Bosco, Lawrence J. Hayward, Robert H. Brown Jr.
Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SJ DFT LEM DAB LJH RHB SL DR GAP. Performed the experiments: SJ DFT HH KD QZ. Analyzed the data: SJ DFT HH KD QZ LEM DAB LJH RHB SL DR GAP. Contributed reagents/materials/analysis tools: SJ DFT HH KD QZ LEM DAB LJH RHB SL. Wrote the paper: SJ DFT HH KD QZ LEM DAB LJH RHB SL DR GAP.