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Research Article

Clusters of Nucleotide Substitutions and Insertion/Deletion Mutations Are Associated with Repeat Sequences

  • Michael J. McDonald equal contributor,

    equal contributor Contributed equally to this work with: Michael J. McDonald, Wei-Chi Wang

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Wei-Chi Wang equal contributor,

    equal contributor Contributed equally to this work with: Michael J. McDonald, Wei-Chi Wang

    Affiliation: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan

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  • Hsien-Da Huang mail,

    bryan@mail.nctu.edu.tw (HDH); jleu@imb.sinica.edu.tw (JYL)

    Affiliations: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan, Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan

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  • Jun-Yi Leu mail

    bryan@mail.nctu.edu.tw (HDH); jleu@imb.sinica.edu.tw (JYL)

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan

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  • Published: June 14, 2011
  • DOI: 10.1371/journal.pbio.1000622

About the Authors

Michael J. McDonald, Jun-Yi Leu
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
Wei-Chi Wang, Hsien-Da Huang
Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Hsinchu, Taiwan
Hsien-Da Huang
Department of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MJM JYL. Performed the experiments: MJM WCW HDH JYL. Analyzed the data: MJM WCW JYL. Contributed reagents/materials/analysis tools: HDH JYL. Wrote the paper: MJM JYL.