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Research Article

Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

  • Zhihui Sun equal contributor,

    equal contributor Contributed equally to this work with: Zhihui Sun, Zamia Diaz

    Affiliation: Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Zamia Diaz equal contributor,

    equal contributor Contributed equally to this work with: Zhihui Sun, Zamia Diaz

    Affiliation: Department of Biochemistry and Biophysics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Xiaodong Fang,

    Affiliation: Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Michael P. Hart,

    Affiliation: Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Alessandra Chesi,

    Affiliation: Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • James Shorter mail,

    gitler@mail.med.upenn.edu (ADG); jshorter@mail.med.upenn.edu (JS)

    Affiliation: Department of Biochemistry and Biophysics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Aaron D. Gitler mail

    gitler@mail.med.upenn.edu (ADG); jshorter@mail.med.upenn.edu (JS)

    Affiliation: Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

    X
  • Published: April 26, 2011
  • DOI: 10.1371/journal.pbio.1000614

About the Authors

Zhihui Sun, Xiaodong Fang, Michael P. Hart, Alessandra Chesi, Aaron D. Gitler
Department of Cell and Developmental Biology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
Zamia Diaz, James Shorter
Department of Biochemistry and Biophysics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ZS ZD XF MPH JS ADG. Performed the experiments: ZS ZD XF MPH JS ADG. Analyzed the data: ZS ZD XF MPH AC JS ADG. Wrote the paper: JS ADG.