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Research Article

Fatty Acid Desaturation Links Germ Cell Loss to Longevity Through NHR-80/HNF4 in C. elegans

  • Jérôme Goudeau,

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Stéphanie Bellemin,

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Esther Toselli-Mollereau,

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Mehrnaz Shamalnasab,

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Yiqun Chen,

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Hugo Aguilaniu mail

    hugo.aguilaniu@ens-lyon.fr

    Affiliation: Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

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  • Published: March 15, 2011
  • DOI: 10.1371/journal.pbio.1000599

About the Authors

Jérôme Goudeau, Stéphanie Bellemin, Esther Toselli-Mollereau, Mehrnaz Shamalnasab, Yiqun Chen, Hugo Aguilaniu
Ecole normale supérieure de Lyon–CNRS–Université de Lyon Claude Bernard, Molecular Biology of the Cell Laboratory/UMR5239, Lyon, France

Corresponding Author

Email: hugo.aguilaniu@ens-lyon.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: JG HA. Performed the experiments: JG SB ETM MS YC. Analyzed the data: JG HA. Contributed reagents/materials/analysis tools: HA. Wrote the paper: HA.