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Research Article

Genome-Wide and Phase-Specific DNA-Binding Rhythms of BMAL1 Control Circadian Output Functions in Mouse Liver

  • Guillaume Rey,

    Affiliations: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Bâtiment Génopode, Université de Lausanne, Lausanne, Switzerland

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  • François Cesbron,

    Affiliation: Biochemistry Center, Universität Heidelberg, Heidelberg, Germany

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  • Jacques Rougemont,

    Affiliations: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Bâtiment Génopode, Université de Lausanne, Lausanne, Switzerland

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  • Hans Reinke,

    Affiliations: Department of Molecular Biology, University of Geneva, Geneva, Switzerland, Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Universität Düsseldorf, Düsseldorf, Germany, Leibniz Institute for Molecular Preventive Medicine, Universität Düsseldorf, Düsseldorf, Germany

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  • Michael Brunner,

    Affiliation: Biochemistry Center, Universität Heidelberg, Heidelberg, Germany

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  • Felix Naef mail

    felix.naef@epfl.ch

    Affiliations: School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics, Bâtiment Génopode, Université de Lausanne, Lausanne, Switzerland

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  • Published: February 22, 2011
  • DOI: 10.1371/journal.pbio.1000595

About the Authors

Guillaume Rey, Jacques Rougemont, Felix Naef
School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Guillaume Rey, Jacques Rougemont, Felix Naef
Swiss Institute of Bioinformatics, Bâtiment Génopode, Université de Lausanne, Lausanne, Switzerland
François Cesbron, Michael Brunner
Biochemistry Center, Universität Heidelberg, Heidelberg, Germany
Hans Reinke
Department of Molecular Biology, University of Geneva, Geneva, Switzerland
Hans Reinke
Medical Faculty, Institute of Clinical Chemistry and Laboratory Diagnostics, Universität Düsseldorf, Düsseldorf, Germany
Hans Reinke
Leibniz Institute for Molecular Preventive Medicine, Universität Düsseldorf, Düsseldorf, Germany

Corresponding Author

Email: felix.naef@epfl.ch

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GR HR MB FN. Performed the experiments: GR FC HR. Analyzed the data: GR JR FN. Contributed reagents/materials/analysis tools: JR MB. Wrote the paper: GR FN.