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Research Article

S. aureus MscL Is a Pentamer In Vivo but of Variable Stoichiometries In Vitro: Implications for Detergent-Solubilized Membrane Proteins

  • Michael R. Dorwart,

    Affiliations: Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Robin Wray,

    Affiliation: Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Chad A. Brautigam,

    Affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Youxing Jiang,

    Affiliations: Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Paul Blount mail

    Paul.Blount@UTSouthwestern.edu

    Affiliation: Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

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  • Published: December 07, 2010
  • DOI: 10.1371/journal.pbio.1000555

About the Authors

Michael R. Dorwart, Robin Wray, Youxing Jiang, Paul Blount
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Michael R. Dorwart, Youxing Jiang
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America
Chad A. Brautigam
Department of Biochemistry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, United States of America

Corresponding Author

Email: Paul.Blount@UTSouthwestern.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MRD RW CAB YJ PB. Performed the experiments: MRD RW CAB. Analyzed the data: MRD RW CAB PB. Wrote the paper: MRD PB.