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Research Article

Domain Swapping in Allosteric Modulation of DNA Specificity

  • Chad K. Park,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Hemant K. Joshi,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

    Current address: Boehringer Ingelheim, St. Joseph, Missouri, United States of America

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  • Alka Agrawal,

    Affiliation: New England Biolabs Inc., Ipswich, Massachusetts, United States of America

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  • M. Imran Ghare,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Elizabeth J. Little,

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

    Current address: Ventana Medical Systems, Tucson, Arizona, United States of America

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  • Pete W. Dunten,

    Affiliation: Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California, United States of America

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  • Jurate Bitinaite,

    Affiliation: New England Biolabs Inc., Ipswich, Massachusetts, United States of America

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  • Nancy C. Horton mail

    nhorton@u.arizona.edu

    Affiliation: Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America

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  • Published: December 07, 2010
  • DOI: 10.1371/journal.pbio.1000554

About the Authors

Chad K. Park, Hemant K. Joshi, M. Imran Ghare, Elizabeth J. Little, Nancy C. Horton
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona, United States of America
Alka Agrawal, Jurate Bitinaite
New England Biolabs Inc., Ipswich, Massachusetts, United States of America
Pete W. Dunten
Stanford Synchrotron Radiation Laboratory, Stanford University, Menlo Park, California, United States of America

Corresponding Author

Email: nhorton@u.arizona.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CKP AA JB NH. Performed the experiments: CKP HKJ AA MIG NH. Analyzed the data: CKP MIG PWD NH. Contributed reagents/materials/analysis tools: CKP AA EJL JB NH. Wrote the paper: CKP JB NH.