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Research Article

Filarial Parasites Develop Faster and Reproduce Earlier in Response to Host Immune Effectors That Determine Filarial Life Expectancy

  • Simon A. Babayan mail,

    s.babayan@ed.ac.uk

    Affiliations: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Andrew F. Read,

    Affiliations: Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom, Center for Infectious Disease Dynamics, Departments of Biology and Entomology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Rachel A. Lawrence,

    Affiliation: Royal Veterinary College, University of London, London, United Kingdom

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  • Odile Bain,

    Affiliation: USM 307, Parasitologie comparée et Modèles expérimentaux, Muséum National d'Histoire Naturelle, Paris, France

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  • Judith E. Allen

    Affiliations: Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom, Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: October 19, 2010
  • DOI: 10.1371/journal.pbio.1000525

About the Authors

Simon A. Babayan, Judith E. Allen
Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom
Simon A. Babayan, Andrew F. Read, Judith E. Allen
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Andrew F. Read
Center for Infectious Disease Dynamics, Departments of Biology and Entomology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
Andrew F. Read
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America
Rachel A. Lawrence
Royal Veterinary College, University of London, London, United Kingdom
Odile Bain
USM 307, Parasitologie comparée et Modèles expérimentaux, Muséum National d'Histoire Naturelle, Paris, France

Corresponding Author

Email: s.babayan@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SAB JEA. Performed the experiments: SAB. Analyzed the data: SAB. Contributed reagents/materials/analysis tools: AFR RAL OB JEA. Wrote the paper: SAB AFR JEA.