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Research Article

Polymorphic Cis- and Trans-Regulation of Human Gene Expression

  • Vivian G. Cheung mail,

    vcheung@mail.med.upenn.edu

    Affiliations: Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Genetics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Renuka R. Nayak,

    Affiliation: Medical Scientist Training Program, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Isabel Xiaorong Wang,

    Affiliation: Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America

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  • Susannah Elwyn,

    Affiliation: University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Sarah M. Cousins,

    Affiliation: University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Michael Morley,

    Affiliation: University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Richard S. Spielman †

    † Deceased.

    Affiliation: Department of Genetics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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  • Published: September 14, 2010
  • DOI: 10.1371/journal.pbio.1000480

About the Authors

Vivian G. Cheung, Isabel Xiaorong Wang
Howard Hughes Medical Institute, Philadelphia, Pennsylvania, United States of America
Vivian G. Cheung
Department of Pediatrics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Vivian G. Cheung, Richard S. Spielman
Department of Genetics, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Vivian G. Cheung, Susannah Elwyn, Sarah M. Cousins, Michael Morley
University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Renuka R. Nayak
Medical Scientist Training Program, University of Pennsylvania, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: vcheung@mail.med.upenn.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: VGC RSS. Performed the experiments: RRN IXW SE. Analyzed the data: VGC RRN IXW SE SMC MM RSS. Wrote the paper: VGC RRN IXW RSS.