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Research Article

The Somatic Reproductive Tissues of C. elegans Promote Longevity through Steroid Hormone Signaling

  • Tracy M. Yamawaki,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Research Institute of Molecular Pathology, Vienna, Austria

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  • Jennifer R. Berman,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Self-employed, Mountain View, California, United States of America

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  • Monika Suchanek-Kavipurapu,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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  • Mark McCormick,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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  • Marta Maria Gaglia,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, United States of America

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  • Seung-Jae Lee,

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

    Current address: Division of Molecular and Life Sciences/I-BIO/World Class University Program IT Convergence Engineering, Pohang University of Science & Technology, Pohang, South Korea

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  • Cynthia Kenyon mail

    cynthia.kenyon@ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

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  • Published: August 31, 2010
  • DOI: 10.1371/journal.pbio.1000468

About the Authors

Tracy M. Yamawaki, Jennifer R. Berman, Monika Suchanek-Kavipurapu, Mark McCormick, Marta Maria Gaglia, Seung-Jae Lee, Cynthia Kenyon
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: cynthia.kenyon@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: TMY CK. Performed the experiments: TMY JRB. Analyzed the data: TMY CK. Contributed reagents/materials/analysis tools: MM MMG SJL. Wrote the paper: TMY CK. Initial work examining the daf-16 requirement for cdr-6 expression in germ cell (−) animals: MSK.