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Research Article

Widespread Protein Aggregation as an Inherent Part of Aging in C. elegans

  • Della C. David,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Noah Ollikainen,

    Affiliation: Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America

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  • Jonathan C. Trinidad,

    Affiliation: Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Michael P. Cary,

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Alma L. Burlingame,

    Affiliation: Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

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  • Cynthia Kenyon mail

    cynthia.kenyon@ucsf.edu

    Affiliation: Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America

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  • Published: August 10, 2010
  • DOI: 10.1371/journal.pbio.1000450

About the Authors

Della C. David, Michael P. Cary, Cynthia Kenyon
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America
Noah Ollikainen
Graduate Program in Biological and Medical Informatics, University of California San Francisco, San Francisco, California, United States of America
Jonathan C. Trinidad, Alma L. Burlingame
Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, United States of America

Corresponding Author

Email: cynthia.kenyon@ucsf.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DCD CK. Performed the experiments: DCD JCT. Analyzed the data: DCD NO MPC. Contributed reagents/materials/analysis tools: JCT ALB. Wrote the paper: DCD CK.