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Research Article

Innate-Like Control of Human iNKT Cell Autoreactivity via the Hypervariable CDR3β Loop

  • Gediminas Matulis,

    Affiliation: Center for Experimental Rheumatology, University of Bern, Inselspital, Bern, Switzerland

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  • Joseph P. Sanderson,

    Affiliation: Division of Infection, Inflammation and Immunity, University of Southampton, School of Medicine, Sir Henry Wellcome and “Hope” Laboratories, United Kingdom

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  • Nikolai M. Lissin,

    Affiliation: Immunocore Ltd., Abingdon, United Kingdom

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  • Maria B. Asparuhova,

    Affiliation: Institute of Cell Biology, University of Bern, Bern, Switzerland

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  • Gopal R. Bommineni,

    Affiliation: Fachbereich Chemie, University of Konstanz, Konstanz, Germany

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  • Daniel Schümperli,

    Affiliation: Institute of Cell Biology, University of Bern, Bern, Switzerland

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  • Richard R. Schmidt,

    Affiliation: Fachbereich Chemie, University of Konstanz, Konstanz, Germany

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  • Peter M. Villiger,

    Affiliation: Center for Experimental Rheumatology, University of Bern, Inselspital, Bern, Switzerland

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  • Bent K. Jakobsen,

    Affiliation: Immunocore Ltd., Abingdon, United Kingdom

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  • Stephan D. Gadola mail

    s.gadola@soton.ac.uk

    Affiliations: Center for Experimental Rheumatology, University of Bern, Inselspital, Bern, Switzerland, Division of Infection, Inflammation and Immunity, University of Southampton, School of Medicine, Sir Henry Wellcome and “Hope” Laboratories, United Kingdom

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  • Published: June 22, 2010
  • DOI: 10.1371/journal.pbio.1000402

About the Authors

Gediminas Matulis, Peter M. Villiger, Stephan D. Gadola
Center for Experimental Rheumatology, University of Bern, Inselspital, Bern, Switzerland
Joseph P. Sanderson, Stephan D. Gadola
Division of Infection, Inflammation and Immunity, University of Southampton, School of Medicine, Sir Henry Wellcome and “Hope” Laboratories, United Kingdom
Nikolai M. Lissin, Bent K. Jakobsen
Immunocore Ltd., Abingdon, United Kingdom
Maria B. Asparuhova, Daniel Schümperli
Institute of Cell Biology, University of Bern, Bern, Switzerland
Gopal R. Bommineni, Richard R. Schmidt
Fachbereich Chemie, University of Konstanz, Konstanz, Germany

Corresponding Author

Email: s.gadola@soton.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: GM SDG. Performed the experiments: GM JPS NML MBA SDG. Analyzed the data: GM JPS NML PMV BKJ SDG. Contributed reagents/materials/analysis tools: MBA GRB DS RRS BKJ SDG. Wrote the paper: JPS SDG.