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Research Article

Molecular Basis for the Dual Function of Eps8 on Actin Dynamics: Bundling and Capping

  • Maud Hertzog equal contributor,

    equal contributor Contributed equally to this work with: Maud Hertzog, Francesca Milanesi

    Affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

    Current address: Institut Curie, Centre de Recherche, Paris, France

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  • Francesca Milanesi equal contributor,

    equal contributor Contributed equally to this work with: Maud Hertzog, Francesca Milanesi

    Affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

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  • Larnele Hazelwood,

    Affiliation: Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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  • Andrea Disanza,

    Affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

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  • HongJun Liu,

    Affiliation: Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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  • Emilie Perlade,

    Affiliation: Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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  • Maria Grazia Malabarba,

    Affiliations: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Milan, Italy

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  • Sebastiano Pasqualato,

    Affiliation: Dipartimento di Oncologia Sperimentale, Istituto Europeo di Oncologia, Milan, Italy

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  • Alessio Maiolica,

    Affiliation: Dipartimento di Oncologia Sperimentale, Istituto Europeo di Oncologia, Milan, Italy

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  • Stefano Confalonieri,

    Affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

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  • Christophe Le Clainche,

    Affiliation: Dynamique du Cytosquelette Laboratoire d'Enzymologie et Biochimie Structurales, Yvette, France

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  • Nina Offenhauser,

    Affiliation: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy

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  • Jennifer Block,

    Affiliation: Cytoskeleton Dynamics Group Helmholtz Centre for Infection Research Inhoffen, Braunschweig, Germany

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  • Klemens Rottner,

    Affiliation: Cytoskeleton Dynamics Group Helmholtz Centre for Infection Research Inhoffen, Braunschweig, Germany

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  • Pier Paolo Di Fiore,

    Affiliations: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Milan, Italy

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  • Marie-France Carlier,

    Affiliation: Dynamique du Cytosquelette Laboratoire d'Enzymologie et Biochimie Structurales, Yvette, France

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  • Niels Volkmann mail,

    niels@burnham.org (NV); dorit@burnham.org (DH); Giorgio.scita@ifom-ieo-campus.it (GS)

    Affiliation: Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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  • Dorit Hanein mail,

    niels@burnham.org (NV); dorit@burnham.org (DH); Giorgio.scita@ifom-ieo-campus.it (GS)

    Affiliation: Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America

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  • Giorgio Scita mail

    niels@burnham.org (NV); dorit@burnham.org (DH); Giorgio.scita@ifom-ieo-campus.it (GS)

    Affiliations: IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy, Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Milan, Italy, Dynamique du Cytosquelette Laboratoire d'Enzymologie et Biochimie Structurales, Yvette, France

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  • Published: June 01, 2010
  • DOI: 10.1371/journal.pbio.1000387

About the Authors

Maud Hertzog, Francesca Milanesi, Andrea Disanza, Maria Grazia Malabarba, Stefano Confalonieri, Nina Offenhauser, Pier Paolo Di Fiore, Giorgio Scita
IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy
Larnele Hazelwood, HongJun Liu, Emilie Perlade, Niels Volkmann, Dorit Hanein
Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, La Jolla, California, United States of America
Maria Grazia Malabarba, Pier Paolo Di Fiore, Giorgio Scita
Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita degli Studi di Milano, Milan, Italy
Sebastiano Pasqualato, Alessio Maiolica
Dipartimento di Oncologia Sperimentale, Istituto Europeo di Oncologia, Milan, Italy
Christophe Le Clainche, Marie-France Carlier, Giorgio Scita
Dynamique du Cytosquelette Laboratoire d'Enzymologie et Biochimie Structurales, Yvette, France
Jennifer Block, Klemens Rottner
Cytoskeleton Dynamics Group Helmholtz Centre for Infection Research Inhoffen, Braunschweig, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MH FM SC KR PPDF NV DH GS. Performed the experiments: MH FM LH AD HL EP SP AM MGM CLC NO JB KR MFC. Analyzed the data: MH FM SP SC MFC NV DH GS. Contributed reagents/materials/analysis tools: MH FM LH AD HL EP CLC. Wrote the paper: MH FM MFC NV DH GS.