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Research Article

Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript

  • Maurice A. Canham,

    Affiliation: Institute for Stem Cell Research, Medical Research Council – Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

    Current address: HPV Research Group, Division of Pathology, School of Molecular and Clinical Medicine, University of Edinburgh, Edinburgh, United Kingdom

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  • Alexei A. Sharov,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health Biomedical Research Center, Baltimore, Maryland, United States of America

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  • Minoru S. H. Ko,

    Affiliation: Laboratory of Genetics, National Institute on Aging, National Institutes of Health Biomedical Research Center, Baltimore, Maryland, United States of America

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  • Joshua M. Brickman mail

    Josh.Brickman@ed.ac.uk

    Affiliation: Institute for Stem Cell Research, Medical Research Council – Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom

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  • Published: May 25, 2010
  • DOI: 10.1371/journal.pbio.1000379

About the Authors

Maurice A. Canham, Joshua M. Brickman
Institute for Stem Cell Research, Medical Research Council – Centre for Regenerative Medicine, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
Alexei A. Sharov, Minoru S. H. Ko
Laboratory of Genetics, National Institute on Aging, National Institutes of Health Biomedical Research Center, Baltimore, Maryland, United States of America

Corresponding Author

Email: Josh.Brickman@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: MAC JMB. Performed the experiments: MAC AAS. Analyzed the data: MAC AAS MSHK JMB. Contributed reagents/materials/analysis tools: MAC MSHK. Wrote the paper: MAC JMB.