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Research Article

Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy

  • Emily S. Sena,

    Affiliations: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, National Stroke Research Institute, Austin Health, University of Melbourne, Melbourne, Victoria, Australia, Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia

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  • H. Bart van der Worp,

    Affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands

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  • Philip M. W. Bath,

    Affiliation: Stroke Trials Unit, University of Nottingham, Nottingham, England, United Kingdom

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  • David W. Howells,

    Affiliations: National Stroke Research Institute, Austin Health, University of Melbourne, Melbourne, Victoria, Australia, Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia

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  • Malcolm R. Macleod mail

    malcolm.macleod@ed.ac.uk

    Affiliations: Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, Department of Neurology, NHS Forth Valley, Stirling, Scotland, United Kingdom

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  • Published: March 30, 2010
  • DOI: 10.1371/journal.pbio.1000344

About the Authors

Emily S. Sena, Malcolm R. Macleod
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom
Emily S. Sena, David W. Howells
National Stroke Research Institute, Austin Health, University of Melbourne, Melbourne, Victoria, Australia
Emily S. Sena, David W. Howells
Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia
H. Bart van der Worp
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
Philip M. W. Bath
Stroke Trials Unit, University of Nottingham, Nottingham, England, United Kingdom
Malcolm R. Macleod
Department of Neurology, NHS Forth Valley, Stirling, Scotland, United Kingdom

Corresponding Author

Email: malcolm.macleod@ed.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ESS HBvdW PMWB DWH MRM. Performed the experiments: ESS. Analyzed the data: ESS MRM. Wrote the paper: ESS HBvdW PMWB DWH MRM. Provided data from systematic reviews: ESS HBvdW PMWB DWH. Provided data from systematic reviews and contributed to the design of the study: MRM.