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Research Article

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

  • Anita B. Hjelmeland mail,

    hjelmea@ccf.org (ABH); richj@ccf.org (JNR)

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Qiulian Wu,

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Sarah Wickman,

    Affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Christine Eyler,

    Affiliations: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • John Heddleston,

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Qing Shi,

    Affiliation: Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Justin D. Lathia,

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Jennifer MacSwords,

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Jeongwu Lee,

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Roger E. McLendon,

    Affiliation: Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

    X
  • Jeremy N. Rich mail

    hjelmea@ccf.org (ABH); richj@ccf.org (JNR)

    Affiliation: Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

    X
  • Published: February 23, 2010
  • DOI: 10.1371/journal.pbio.1000319

About the Authors

Anita B. Hjelmeland, Qiulian Wu, Christine Eyler, John Heddleston, Justin D. Lathia, Jennifer MacSwords, Jeongwu Lee, Jeremy N. Rich
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America
Sarah Wickman, Christine Eyler, Qing Shi
Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America
Roger E. McLendon
Department of Pathology, Duke University Medical Center, Durham, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ABH JNR. Performed the experiments: ABH QW SW CE JH QS JDL JM. Analyzed the data: ABH QW SW QS. Contributed reagents/materials/analysis tools: JL REM. Wrote the paper: ABH JNR.