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Research Article

Regulatory T Cells and Human Myeloid Dendritic Cells Promote Tolerance via Programmed Death Ligand-1

  • Shoba Amarnath mail,

    samarnath@mail.nih.gov

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Carliann M. Costanzo,

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jacopo Mariotti,

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Jessica L. Ullman,

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • William G. Telford,

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Veena Kapoor,

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • James L. Riley,

    Affiliation: University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, United States of America

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  • Bruce L. Levine,

    Affiliation: University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, United States of America

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  • Carl H. June,

    Affiliation: University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, United States of America

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  • Timothy Fong,

    Affiliation: BD BioSciences, San Jose, California, United States of America

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  • Noel L. Warner,

    Affiliation: BD BioSciences, San Jose, California, United States of America

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  • Daniel H. Fowler

    Affiliation: Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: February 02, 2010
  • DOI: 10.1371/journal.pbio.1000302

About the Authors

Shoba Amarnath, Carliann M. Costanzo, Jacopo Mariotti, Jessica L. Ullman, William G. Telford, Veena Kapoor, Daniel H. Fowler
Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
James L. Riley, Bruce L. Levine, Carl H. June
University of Pennsylvania, Abramson Family Cancer Research Institute, Philadelphia, Pennsylvania, United States of America
Timothy Fong, Noel L. Warner
BD BioSciences, San Jose, California, United States of America

Corresponding Author

Email: samarnath@mail.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SA JLR BLL CHJ DHF. Performed the experiments: SA CMC JM JLU WGT VK. Analyzed the data: SA CMC JM JLU WGT VK JLR BLL CHJ. Contributed reagents/materials/analysis tools: BLL CHJ TF NLW. Wrote the paper: SA DHF.