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Research Article

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

  • Derek P. Narendra,

    Affiliation: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Seok Min Jin,

    Affiliation: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Atsushi Tanaka,

    Affiliation: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Der-Fen Suen,

    Affiliation: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Clement A. Gautier,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Jie Shen,

    Affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America

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  • Mark R. Cookson,

    Affiliation: Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

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  • Richard J. Youle mail

    youler@ninds.nih.gov

    Affiliation: Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pbio.1000298

About the Authors

Derek P. Narendra, Seok Min Jin, Atsushi Tanaka, Der-Fen Suen, Richard J. Youle
Biochemistry Section, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
Clement A. Gautier, Jie Shen
Center for Neurologic Diseases, Brigham and Women's Hospital, Program in Neuroscience, Harvard Medical School, Boston, Massachusetts, United States of America
Mark R. Cookson
Cell Biology and Gene Expression Unit, Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, United States of America

Corresponding Author

Email: youler@ninds.nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DPN SMJ AT DFS RJY. Performed the experiments: DPN SMJ AT. Analyzed the data: DPN SMJ AT MRC RJY. Contributed reagents/materials/analysis tools: CAG JS RJY. Wrote the paper: DPN RJY.