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Research Article

Rare Variants Create Synthetic Genome-Wide Associations

  • Samuel P. Dickson,

    Affiliations: Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America, Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America

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  • Kai Wang,

    Affiliation: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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  • Ian Krantz,

    Affiliations: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • Hakon Hakonarson,

    Affiliations: Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America, Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

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  • David B. Goldstein mail

    d.goldstein@duke.edu

    Affiliation: Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America

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  • Published: January 26, 2010
  • DOI: 10.1371/journal.pbio.1000294

About the Authors

Samuel P. Dickson, David B. Goldstein
Institute for Genome Sciences and Policy, Center for Human Genome Variation, Duke University, Durham, North Carolina, United States of America
Samuel P. Dickson
Bioinformatics Research Center, North Carolina State University, Raleigh, North Carolina, United States of America
Kai Wang, Ian Krantz, Hakon Hakonarson
Center for Applied Genomics, Children's Hospital of Pennsylvania, Philadelphia, Pennsylvania, United States of America
Ian Krantz, Hakon Hakonarson
Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
Ian Krantz, Hakon Hakonarson
Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: d.goldstein@duke.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: SPD DBG. Performed the experiments: SPD HH. Analyzed the data: SPD KW. Contributed reagents/materials/analysis tools: IK. Wrote the paper: SPD KW HH DBG.