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Research Article

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

  • Daniel W. Neef,

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Michelle L. Turski,

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Dennis J. Thiele mail

    dennis.thiele@duke.edu

    Affiliation: Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pbio.1000291

About the Authors

Daniel W. Neef, Michelle L. Turski, Dennis J. Thiele
Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, United States of America

Corresponding Author

Email: dennis.thiele@duke.edu

Competing Interests

Duke University has filed a patent application for the screening technology described in this report as well as the small molecules identified via this screening technology.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: DWN DJT. Performed the experiments: DWN MLT. Analyzed the data: DWN DJT. Wrote the paper: DWN DJT.