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Research Article

Neuron Specific Rab4 Effector GRASP-1 Coordinates Membrane Specialization and Maturation of Recycling Endosomes

  • Casper C. Hoogenraad mail,

    c.hoogenraad@erasmusmc.nl (CCH); p.vandersluijs@umcutrecht.nl (PvdS)

    Affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Ioana Popa,

    Affiliation: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands

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  • Kensuke Futai,

    Affiliation: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Emma Sanchez-Martinez,

    Affiliation: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands

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  • Phebe S. Wulf,

    Affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Thijs van Vlijmen,

    Affiliation: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands

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  • Bjorn R. Dortland,

    Affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Viola Oorschot,

    Affiliations: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands, Cell Microscopy Center, UMC Utrecht, Utrecht, The Netherlands

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  • Roland Govers,

    Affiliation: Department of Functional Genomics, Centre for Neurogenomics and Cognitive Research, VU Amsterdam, The Netherlands

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  • Maria Monti,

    Affiliation: Department of Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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  • Albert J. R. Heck,

    Affiliation: Department of Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands

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  • Morgan Sheng,

    Affiliation: The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Judith Klumperman,

    Affiliations: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands, Cell Microscopy Center, UMC Utrecht, Utrecht, The Netherlands

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  • Holger Rehmann,

    Affiliation: Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands

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  • Dick Jaarsma,

    Affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Lukas C. Kapitein,

    Affiliation: Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands

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  • Peter van der Sluijs mail

    c.hoogenraad@erasmusmc.nl (CCH); p.vandersluijs@umcutrecht.nl (PvdS)

    Affiliation: Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands

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  • Published: January 19, 2010
  • DOI: 10.1371/journal.pbio.1000283

About the Authors

Casper C. Hoogenraad, Phebe S. Wulf, Bjorn R. Dortland, Dick Jaarsma, Lukas C. Kapitein
Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
Ioana Popa, Emma Sanchez-Martinez, Thijs van Vlijmen, Viola Oorschot, Judith Klumperman, Peter van der Sluijs
Department of Cell Biology, University Medical Center (UMC) Utrecht, Utrecht, The Netherlands
Kensuke Futai, Morgan Sheng
The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Viola Oorschot, Judith Klumperman
Cell Microscopy Center, UMC Utrecht, Utrecht, The Netherlands
Roland Govers
Department of Functional Genomics, Centre for Neurogenomics and Cognitive Research, VU Amsterdam, The Netherlands
Maria Monti, Albert J. R. Heck
Department of Biomolecular Mass Spectrometry and Proteomics Group, Bijvoet Centre for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
Holger Rehmann
Department of Physiological Chemistry, Centre for Biomedical Genetics and Cancer Genomics Centre, UMC Utrecht, Utrecht, The Netherlands

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: CCH PvdS. Performed the experiments: CCH IP KF ESM PSW TvV BRD VO MM HR DJ LCK PvdS. Analyzed the data: CCH IP KF BRD LCK PvdS. Contributed reagents/materials/analysis tools: RG AJRH MS JK. Wrote the paper: CCH PvdS.