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Research Article

Global Conformational Dynamics of a Y-Family DNA Polymerase during Catalysis

  • Cuiling Xu,

    Affiliation: Department of Biochemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Brian A. Maxwell,

    Affiliation: Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio, United States of America

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  • Jessica A. Brown,

    Affiliations: Department of Biochemistry, The Ohio State University, Columbus, Ohio, United States of America, Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America

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  • Likui Zhang,

    Affiliation: Department of Biochemistry, The Ohio State University, Columbus, Ohio, United States of America

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  • Zucai Suo mail

    suo.3@osu.edu

    Affiliations: Department of Biochemistry, The Ohio State University, Columbus, Ohio, United States of America, Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio, United States of America, Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America, Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

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  • Published: October 27, 2009
  • DOI: 10.1371/journal.pbio.1000225

About the Authors

Cuiling Xu, Jessica A. Brown, Likui Zhang, Zucai Suo
Department of Biochemistry, The Ohio State University, Columbus, Ohio, United States of America
Brian A. Maxwell, Zucai Suo
Ohio State Biophysics Program, The Ohio State University, Columbus, Ohio, United States of America
Jessica A. Brown, Zucai Suo
Ohio State Biochemistry Program, The Ohio State University, Columbus, Ohio, United States of America
Zucai Suo
Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Columbus, Ohio, United States of America
Zucai Suo
Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Author

Email: suo.3@osu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: ZS. Performed the experiments: CX BAM JAB LZ. Analyzed the data: CX BAM JAB LZ ZS. Wrote the paper: CX BAM JAB ZS.