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Research Article

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

  • Peter W. Janes equal contributor,

    equal contributor Contributed equally to this work with: Peter W. Janes, Sabine H. Wimmer-Kleikamp

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia

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  • Sabine H. Wimmer-Kleikamp equal contributor,

    equal contributor Contributed equally to this work with: Peter W. Janes, Sabine H. Wimmer-Kleikamp

    Affiliations: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia, European Molecular Biology Laboratory, Heidelberg, Germany, Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

    Current address: Centre for Vascular Research, School of Medical Sciences, The University of Sydney, Medical Foundation, Camperdown, New South Wales, Australia

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  • Achilleas S. Frangakis,

    Affiliation: European Molecular Biology Laboratory, Heidelberg, Germany

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  • Kane Treble,

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia

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  • Bettina Griesshaber,

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia

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  • Ola Sabet,

    Affiliation: Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

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  • Markus Grabenbauer,

    Affiliation: Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

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  • Alice Y. Ting,

    Affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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  • Paul Saftig,

    Affiliation: Biochemical Institute, Christian-Albrecht-University, Kiel, Germany

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  • Philippe I. Bastiaens mail,

    philippe.bastiaens@mpi-dortmund.mpg.de (PIB); martin.lackmann@med.monash.edu.au (ML)

    Affiliations: European Molecular Biology Laboratory, Heidelberg, Germany, Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

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  • Martin Lackmann mail

    philippe.bastiaens@mpi-dortmund.mpg.de (PIB); martin.lackmann@med.monash.edu.au (ML)

    Affiliation: Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia

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  • Published: October 13, 2009
  • DOI: 10.1371/journal.pbio.1000215

About the Authors

Peter W. Janes, Sabine H. Wimmer-Kleikamp, Kane Treble, Bettina Griesshaber, Martin Lackmann
Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia
Sabine H. Wimmer-Kleikamp, Achilleas S. Frangakis, Philippe I. Bastiaens
European Molecular Biology Laboratory, Heidelberg, Germany
Sabine H. Wimmer-Kleikamp, Ola Sabet, Markus Grabenbauer, Philippe I. Bastiaens
Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany
Alice Y. Ting
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
Paul Saftig
Biochemical Institute, Christian-Albrecht-University, Kiel, Germany

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: PWJ SHWK ASF PIB ML. Performed the experiments: PWJ SHWK KT BG OS. Analyzed the data: PWJ SHWK ASF PIB ML. Contributed reagents/materials/analysis tools: ASF MG AYT PS. Wrote the paper: PWJ PIB ML.