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Research Article

Exploration of Uncharted Regions of the Protein Universe

  • Lukasz Jaroszewski,

    Affiliation: Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Zhanwen Li,

    Affiliation: Joint Center for Molecular Modeling, Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • S. Sri Krishna,

    Affiliation: Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • Constantina Bakolitsa,

    Affiliation: Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America

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  • John Wooley,

    Affiliation: Joint Center for Structural Genomics, Bioinformatics Core, Center for Research in Biological Systems, University of California San Diego, La Jolla, California, United States of America

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  • Ashley M. Deacon,

    Affiliation: Joint Center for Structural Genomics, Structure Determination Core, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America

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  • Ian A. Wilson,

    Affiliation: Joint Center for Structural Genomics, The Scripps Research Institute, La Jolla, California, United States of America

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  • Adam Godzik mail

    adam@burnham.org

    Affiliations: Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America, Joint Center for Molecular Modeling, Burnham Institute for Medical Research, La Jolla, California, United States of America, Joint Center for Structural Genomics, Bioinformatics Core, Center for Research in Biological Systems, University of California San Diego, La Jolla, California, United States of America

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  • Published: September 29, 2009
  • DOI: 10.1371/journal.pbio.1000205

About the Authors

Lukasz Jaroszewski, S. Sri Krishna, Constantina Bakolitsa, Adam Godzik
Joint Center for Structural Genomics, Bioinformatics Core, Burnham Institute for Medical Research, La Jolla, California, United States of America
Zhanwen Li, Adam Godzik
Joint Center for Molecular Modeling, Burnham Institute for Medical Research, La Jolla, California, United States of America
John Wooley, Adam Godzik
Joint Center for Structural Genomics, Bioinformatics Core, Center for Research in Biological Systems, University of California San Diego, La Jolla, California, United States of America
Ashley M. Deacon
Joint Center for Structural Genomics, Structure Determination Core, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, California, United States of America
Ian A. Wilson
Joint Center for Structural Genomics, The Scripps Research Institute, La Jolla, California, United States of America

Corresponding Author

Email: adam@burnham.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

The author(s) have made the following declarations about their contributions: Conceived and designed the experiments: LJ AG. Performed the experiments: LJ ZL AMD AG. Analyzed the data: LJ ZL SKS CB AMD AG. Contributed reagents/materials/analysis tools: LJ ZL AG. Wrote the paper: LJ JW AMD IAW AG.